产品描述
onocyte colony-stimulating factor (M-CSF, CSF-1) is a macrophage lineage-specific growth factor. Full length human M-CSF transcripts encode a 522 amino acid (aa) type I transmembrane (TM) protein with a 464 aa extracellular region, a 21 aa TM domain, and a 37 aa cytoplasmic tail that forms a 140 kDa covalent dimer. The first 223 aa of mature human M-CSF shares 88%, 86%, 81% and 74% aa identity with corresponding regions of dog, cow, mouse and rat MCSF, respectively. M-CSF Induces vascular endothelial growth factor production and angiogenic activity from human monocytes. Whatmore, M-CSF and GM-CSF are mediators involved in regulating the numbers and function of macrophage lineage populations and have been shown to contribute to macrophage heterogeneity.
产品参数
别名(Synonyms) |
IL-17E, IL-25, MYDGF |
Accession |
Q9CPT4 |
GeneID |
28106 |
表达系统(Source) |
E.coli-derived Mouse SF-20/IL-25, Val25-Leu166, with an N-terminal Met. |
分子量大小(Molecular Weight) |
Approximately 15.8 kDa. |
氨基酸序列(AA Sequence) |
MVSEPTTVPF DVRPGGVVHS FSQDVGPGNK FTCTFTYASQ GGTNEQWQMS LGTSEDSQHF TCTIWRPQGK SYLYFTQFKA ELRGAEIEYA MAYSKAAFER ESDVPLKSEE FEVTKTAVSH RPGAFKAELS KLVIVAKAAR SEL |
标签(Tag) |
None |
外观(Physical Appearance) |
Sterile Filtered White lyophilized (freeze-dried) powder. |
纯度(Purity) |
> 95% by SDS-PAGE and HPLC analyses. |
生物活性(Biological Activity) |
Data Not Available. |
内毒素(Endotoxin) |
< 1.0 EU per 1μg of the protein by the LAL method. |
制剂(Formulation) |
Lyophilized from a 0.2 μm filtered concentrated solution in PBS, pH 7.4. |
复溶(Reconstitution) |
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤ -20°C. Further dilutions should be made in appropriate buffered solutions. |
储存条件
产品用冰袋装运,可在-20℃至-80℃下保存1年。
建议第一次使用时将蛋白质分成较小的量,并避免反复冻融循环。
注意事项
1.避免反复冻融循环。
2.为了您的安全和健康,请穿实验服,戴一次性手套进行操作。
3.仅供研究使用!
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